One thing I've learned from years of traveling is never unpack everything until you know the room is ok.
By "ok," I mean it has no unusual odors, unidentifiable organic-appearing substances on any surfaces, working electrical outlets, functional plumbing and HVAC systems.
Just because you're staying in a hotel with a name and reputation doesn't mean everything's going to be satisfactory.
The hotel here in Rockville, Maryland is nice, but I couldn't get the room temperature below 75°, which is far too warm for my comfort. Engineering gave me instructions to reset the unit. I did, napped for a few hours, and awoke to... 76°. This was not trending well.
A call to the front desk, and I was instantly assigned to another room with a functional air conditioner. All I had to do was throw the laptop and battery into my backpack because I hadn't unpacked anything else. Sometimes it takes a few hours for a room's flaws to reveal themselves.
Of course, as you can tell from the time of this post, today is going to be a long day.
I think I'll begin it with a nap.